Designing Biomaterials Both High In Rigidity And Bioactivity
Biomaterials are ubiquitous in modern medicine, from prosthetic limbs to device coatings, and hold promise for future applications like scaffolding for tissue regeneration. Biomaterial design presents a key challenge, however: applications often require materials to be both mechanically rigid (to promote strong cell adhesion) and bioactive (i.e. able to communicate specific cues to contacting cells). To date, achieving one of these features usually required sacrificing the other. “Increasing film rigidity through chemical crosslinking often suppresses film bioactivity, whether by inhibiting the mobility or accessibility of embedded biomolecules or by chemically altering them,” says Connie Wu, a chemical engineering undergraduate student and lead author of the paper....